Granadilla de Abona is located in the south of Tenerife (Canary Islands) and covers an area of 155 km2, making it the third largest municipality on the island. It stretches from the coast to the summit, crowned by the Guajara mountain at an altitude of 2,718 metres, the second highest peak in the archipelago, which overlooks the sea as one of the most emblematic natural elements of the island.

To the east, it borders the municipality of Arico along the deep and once plentiful El Río ravine. To the northwest, it borders the municipality of Vilaflor de Chasna and to the west with the municipality of San Miguel de Abona, separated from both by the deep ravine of La Orchilla. In more detail, from east to west, the municipality runs from the Barranco del Río, mentioned in 'Las Datas' of land distribution, as the river of Abona and the municipal boundary of Arico, since the municipalities were formed, to the Orchilla ravine in the west, which also forms the boundary with San Miguel de Abona; a ravine mentioned in the aforementioned datas as the river of Chasna (land therefore that of Granadilla, bathed between rivers). The landscape is fairly open and clear, with a more gentle slope than in other parts of the island, which is why these fertile plains have seemed suitable for cultivation since the first settlers arrived.

Together with Fasnia, Arico, Vilaflor, San Miguel and Arona, Granadilla forms the district of Chasna, an area that also included the ancient menceyato or aboriginal kingdom of Abona.